A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.
Identifieur interne : 003229 ( Main/Exploration ); précédent : 003228; suivant : 003230A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.
Auteurs : E M Hersh [États-Unis] ; M. Del Vecchio [Italie] ; M P Brown ; R. Kefford [Australie] ; C. Loquai [Allemagne] ; A. Testori [Italie] ; S. Bhatia [États-Unis] ; R. Gutzmer [Allemagne] ; R. Conry [États-Unis] ; A. Haydon [Australie] ; C. Robert [France] ; S. Ernst [Canada] ; J. Homsi [États-Unis] ; J J Grob [France] ; K. Kendra ; S S Agarwala ; M. Li [États-Unis] ; A. Clawson [États-Unis] ; C. Brachmann [États-Unis] ; M. Karnoub [États-Unis] ; I. Elias [États-Unis] ; M F Renschler [États-Unis] ; A. Hauschild [Allemagne]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Albumines (usage thérapeutique), Antinéoplasiques alcoylants (usage thérapeutique), Dacarbazine (usage thérapeutique), Femelle, Humains, Jeune adulte, Mâle, Mélanome (diagnostic), Mélanome (traitement médicamenteux), Paclitaxel (usage thérapeutique), Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs cutanées (diagnostic), Tumeurs cutanées (traitement médicamenteux).
- MESH :
- diagnostic : Mélanome, Tumeurs cutanées.
- traitement médicamenteux : Mélanome, Tumeurs cutanées.
- usage thérapeutique : Albumines, Antinéoplasiques alcoylants, Dacarbazine, Paclitaxel.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Albumins (therapeutic use), Antineoplastic Agents, Alkylating (therapeutic use), Dacarbazine (therapeutic use), Disease-Free Survival, Female, Humans, Male, Melanoma (diagnosis), Melanoma (drug therapy), Middle Aged, Paclitaxel (therapeutic use), Skin Neoplasms (diagnosis), Skin Neoplasms (drug therapy), Young Adult.
- MESH :
- chemical , therapeutic use : Albumins, Antineoplastic Agents, Alkylating, Dacarbazine, Paclitaxel.
- diagnosis : Melanoma, Skin Neoplasms.
- drug therapy : Melanoma, Skin Neoplasms.
- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
The efficacy and safety of nab-paclitaxel versus dacarbazine in patients with metastatic melanoma was evaluated in a phase III randomized, controlled trial.
DOI: 10.1093/annonc/mdv324
PubMed: 26410620
Affiliations:
- Allemagne, Australie, Canada, France, Italie, États-Unis
- Angleterre, Basse-Saxe, Grand Londres, Lombardie, Midlands de l'Ouest, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Rhénanie-Palatinat, Schleswig-Holstein, Victoria (État)
- Birmingham, Hanovre, Kiel, Londres, Marseille, Mayence, Melbourne, Milan, Sydney
- Université de Sydney
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Le document en format XML
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Del Vecchio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS National Tumor Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS National Tumor Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Brown, M P" sort="Brown, M P" uniqKey="Brown M" first="M P" last="Brown">M P Brown</name><affiliation><nlm:affiliation>Cancer Clinical Trials Unit, Royal Adelaide Hospital and School of Medicine, University of Adelaide, Adelaide.</nlm:affiliation><wicri:noCountry code="subField">Adelaide</wicri:noCountry></affiliation></author><author><name sortKey="Kefford, R" sort="Kefford, R" uniqKey="Kefford R" first="R" last="Kefford">R. Kefford</name><affiliation wicri:level="4"><nlm:affiliation>Sydney West Cancer Trials Centre/Westmead Hospital and Melanoma Institute Australia, University of Sydney, North Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney West Cancer Trials Centre/Westmead Hospital and Melanoma Institute Australia, University of Sydney, North Sydney</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Loquai, C" sort="Loquai, C" uniqKey="Loquai C" first="C" last="Loquai">C. 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Testori</name><affiliation wicri:level="3"><nlm:affiliation>Melanoma and Muscle Cutaneous Sarcoma Division, European Institute of Oncology, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma and Muscle Cutaneous Sarcoma Division, European Institute of Oncology, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bhatia, S" sort="Bhatia, S" uniqKey="Bhatia S" first="S" last="Bhatia">S. Bhatia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Seattle Cancer Care Alliance, Seattle, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Seattle Cancer Care Alliance, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Gutzmer, R" sort="Gutzmer, R" uniqKey="Gutzmer R" first="R" last="Gutzmer">R. Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Oncology, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Conry, R" sort="Conry, R" uniqKey="Conry R" first="R" last="Conry">R. Conry</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Haydon, A" sort="Haydon, A" uniqKey="Haydon A" first="A" last="Haydon">A. Haydon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C" last="Robert">C. Robert</name><affiliation wicri:level="1"><nlm:affiliation>Demartology Unit, Department of Medicine, The Gustave Roussy Cancer Institute, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Demartology Unit, Department of Medicine, The Gustave Roussy Cancer Institute, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Ernst, S" sort="Ernst, S" uniqKey="Ernst S" first="S" last="Ernst">S. Ernst</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, London Health Sciences Center-London Regional Cancer Program, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology, London Health Sciences Center-London Regional Cancer Program, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Homsi, J" sort="Homsi, J" uniqKey="Homsi J" first="J" last="Homsi">J. Homsi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Banner MD Anderson Cancer Center, Gilbert, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Banner MD Anderson Cancer Center, Gilbert</wicri:regionArea><wicri:noRegion>Gilbert</wicri:noRegion></affiliation></author><author><name sortKey="Grob, J J" sort="Grob, J J" uniqKey="Grob J" first="J J" last="Grob">J J Grob</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Timone Hospital, APHM and Aix-Marseille University, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Timone Hospital, APHM and Aix-Marseille University, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Kendra, K" sort="Kendra, K" uniqKey="Kendra K" first="K" last="Kendra">K. Kendra</name><affiliation><nlm:affiliation>Department of Internal Medicine, Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus.</nlm:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation></author><author><name sortKey="Agarwala, S S" sort="Agarwala, S S" uniqKey="Agarwala S" first="S S" last="Agarwala">S S Agarwala</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, St Luke's Cancer Center and Temple University, Bethlehem.</nlm:affiliation><wicri:noCountry code="subField">Bethlehem</wicri:noCountry></affiliation></author><author><name sortKey="Li, M" sort="Li, M" uniqKey="Li M" first="M" last="Li">M. Li</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Clawson, A" sort="Clawson, A" uniqKey="Clawson A" first="A" last="Clawson">A. Clawson</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Brachmann, C" sort="Brachmann, C" uniqKey="Brachmann C" first="C" last="Brachmann">C. Brachmann</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Karnoub, M" sort="Karnoub, M" uniqKey="Karnoub M" first="M" last="Karnoub">M. Karnoub</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Elias, I" sort="Elias, I" uniqKey="Elias I" first="I" last="Elias">I. Elias</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Renschler, M F" sort="Renschler, M F" uniqKey="Renschler M" first="M F" last="Renschler">M F Renschler</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Hauschild, A" sort="Hauschild, A" uniqKey="Hauschild A" first="A" last="Hauschild">A. Hauschild</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26410620</idno><idno type="pmid">26410620</idno><idno type="doi">10.1093/annonc/mdv324</idno><idno type="wicri:Area/PubMed/Corpus">002726</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002726</idno><idno type="wicri:Area/PubMed/Curation">002657</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002657</idno><idno type="wicri:Area/PubMed/Checkpoint">002657</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002657</idno><idno type="wicri:Area/Ncbi/Merge">002B25</idno><idno type="wicri:Area/Ncbi/Curation">002B25</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B25</idno><idno type="wicri:Area/Main/Merge">003230</idno><idno type="wicri:Area/Main/Curation">003229</idno><idno type="wicri:Area/Main/Exploration">003229</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.</title><author><name sortKey="Hersh, E M" sort="Hersh, E M" uniqKey="Hersh E" first="E M" last="Hersh">E M Hersh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Arizona Cancer Center, Tucson, USA ehersh@azcc.arizona.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Medicine, Arizona Cancer Center, Tucson</wicri:regionArea><wicri:noRegion>Tucson</wicri:noRegion></affiliation></author><author><name sortKey="Del Vecchio, M" sort="Del Vecchio, M" uniqKey="Del Vecchio M" first="M" last="Del Vecchio">M. Del Vecchio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS National Tumor Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS National Tumor Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Brown, M P" sort="Brown, M P" uniqKey="Brown M" first="M P" last="Brown">M P Brown</name><affiliation><nlm:affiliation>Cancer Clinical Trials Unit, Royal Adelaide Hospital and School of Medicine, University of Adelaide, Adelaide.</nlm:affiliation><wicri:noCountry code="subField">Adelaide</wicri:noCountry></affiliation></author><author><name sortKey="Kefford, R" sort="Kefford, R" uniqKey="Kefford R" first="R" last="Kefford">R. Kefford</name><affiliation wicri:level="4"><nlm:affiliation>Sydney West Cancer Trials Centre/Westmead Hospital and Melanoma Institute Australia, University of Sydney, North Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney West Cancer Trials Centre/Westmead Hospital and Melanoma Institute Australia, University of Sydney, North Sydney</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Loquai, C" sort="Loquai, C" uniqKey="Loquai C" first="C" last="Loquai">C. Loquai</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University of Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University of Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Testori, A" sort="Testori, A" uniqKey="Testori A" first="A" last="Testori">A. Testori</name><affiliation wicri:level="3"><nlm:affiliation>Melanoma and Muscle Cutaneous Sarcoma Division, European Institute of Oncology, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma and Muscle Cutaneous Sarcoma Division, European Institute of Oncology, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bhatia, S" sort="Bhatia, S" uniqKey="Bhatia S" first="S" last="Bhatia">S. Bhatia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Seattle Cancer Care Alliance, Seattle, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Seattle Cancer Care Alliance, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Gutzmer, R" sort="Gutzmer, R" uniqKey="Gutzmer R" first="R" last="Gutzmer">R. Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Oncology, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Conry, R" sort="Conry, R" uniqKey="Conry R" first="R" last="Conry">R. Conry</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Haydon, A" sort="Haydon, A" uniqKey="Haydon A" first="A" last="Haydon">A. Haydon</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Alfred Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C" last="Robert">C. Robert</name><affiliation wicri:level="1"><nlm:affiliation>Demartology Unit, Department of Medicine, The Gustave Roussy Cancer Institute, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Demartology Unit, Department of Medicine, The Gustave Roussy Cancer Institute, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Ernst, S" sort="Ernst, S" uniqKey="Ernst S" first="S" last="Ernst">S. Ernst</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, London Health Sciences Center-London Regional Cancer Program, London, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology, London Health Sciences Center-London Regional Cancer Program, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Homsi, J" sort="Homsi, J" uniqKey="Homsi J" first="J" last="Homsi">J. Homsi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Banner MD Anderson Cancer Center, Gilbert, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Banner MD Anderson Cancer Center, Gilbert</wicri:regionArea><wicri:noRegion>Gilbert</wicri:noRegion></affiliation></author><author><name sortKey="Grob, J J" sort="Grob, J J" uniqKey="Grob J" first="J J" last="Grob">J J Grob</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Timone Hospital, APHM and Aix-Marseille University, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Timone Hospital, APHM and Aix-Marseille University, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Kendra, K" sort="Kendra, K" uniqKey="Kendra K" first="K" last="Kendra">K. Kendra</name><affiliation><nlm:affiliation>Department of Internal Medicine, Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus.</nlm:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation></author><author><name sortKey="Agarwala, S S" sort="Agarwala, S S" uniqKey="Agarwala S" first="S S" last="Agarwala">S S Agarwala</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, St Luke's Cancer Center and Temple University, Bethlehem.</nlm:affiliation><wicri:noCountry code="subField">Bethlehem</wicri:noCountry></affiliation></author><author><name sortKey="Li, M" sort="Li, M" uniqKey="Li M" first="M" last="Li">M. Li</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Clawson, A" sort="Clawson, A" uniqKey="Clawson A" first="A" last="Clawson">A. Clawson</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Brachmann, C" sort="Brachmann, C" uniqKey="Brachmann C" first="C" last="Brachmann">C. Brachmann</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Karnoub, M" sort="Karnoub, M" uniqKey="Karnoub M" first="M" last="Karnoub">M. Karnoub</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Elias, I" sort="Elias, I" uniqKey="Elias I" first="I" last="Elias">I. Elias</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Renschler, M F" sort="Renschler, M F" uniqKey="Renschler M" first="M F" last="Renschler">M F Renschler</name><affiliation wicri:level="1"><nlm:affiliation>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biometrics and Data Operations/Translational Medicine/Biometrics and Data Operations/Clinical Research & Development/Global Medical Affairs, Celgene Corporation, Summit</wicri:regionArea><wicri:noRegion>Summit</wicri:noRegion></affiliation></author><author><name sortKey="Hauschild, A" sort="Hauschild, A" uniqKey="Hauschild A" first="A" last="Hauschild">A. Hauschild</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Medical Center Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Albumins (therapeutic use)</term><term>Antineoplastic Agents, Alkylating (therapeutic use)</term><term>Dacarbazine (therapeutic use)</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Male</term><term>Melanoma (diagnosis)</term><term>Melanoma (drug therapy)</term><term>Middle Aged</term><term>Paclitaxel (therapeutic use)</term><term>Skin Neoplasms (diagnosis)</term><term>Skin Neoplasms (drug therapy)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Albumines (usage thérapeutique)</term><term>Antinéoplasiques alcoylants (usage thérapeutique)</term><term>Dacarbazine (usage thérapeutique)</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Mélanome (diagnostic)</term><term>Mélanome (traitement médicamenteux)</term><term>Paclitaxel (usage thérapeutique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tumeurs cutanées (diagnostic)</term><term>Tumeurs cutanées (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albumins</term><term>Antineoplastic Agents, Alkylating</term><term>Dacarbazine</term><term>Paclitaxel</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Melanoma</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Mélanome</term><term>Tumeurs cutanées</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term><term>Tumeurs cutanées</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albumines</term><term>Antinéoplasiques alcoylants</term><term>Dacarbazine</term><term>Paclitaxel</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The efficacy and safety of nab-paclitaxel versus dacarbazine in patients with metastatic melanoma was evaluated in a phase III randomized, controlled trial.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Grand Londres</li><li>Lombardie</li><li>Midlands de l'Ouest</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhénanie-Palatinat</li><li>Schleswig-Holstein</li><li>Victoria (État)</li></region><settlement><li>Birmingham</li><li>Hanovre</li><li>Kiel</li><li>Londres</li><li>Marseille</li><li>Mayence</li><li>Melbourne</li><li>Milan</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><noCountry><name sortKey="Agarwala, S S" sort="Agarwala, S S" uniqKey="Agarwala S" first="S S" last="Agarwala">S S Agarwala</name><name sortKey="Brown, M P" sort="Brown, M P" uniqKey="Brown M" first="M P" last="Brown">M P Brown</name><name sortKey="Kendra, K" sort="Kendra, K" uniqKey="Kendra K" first="K" last="Kendra">K. Kendra</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Hersh, E M" sort="Hersh, E M" uniqKey="Hersh E" first="E M" last="Hersh">E M Hersh</name></noRegion><name sortKey="Bhatia, S" sort="Bhatia, S" uniqKey="Bhatia S" first="S" last="Bhatia">S. Bhatia</name><name sortKey="Brachmann, C" sort="Brachmann, C" uniqKey="Brachmann C" first="C" last="Brachmann">C. Brachmann</name><name sortKey="Clawson, A" sort="Clawson, A" uniqKey="Clawson A" first="A" last="Clawson">A. Clawson</name><name sortKey="Conry, R" sort="Conry, R" uniqKey="Conry R" first="R" last="Conry">R. Conry</name><name sortKey="Elias, I" sort="Elias, I" uniqKey="Elias I" first="I" last="Elias">I. Elias</name><name sortKey="Homsi, J" sort="Homsi, J" uniqKey="Homsi J" first="J" last="Homsi">J. Homsi</name><name sortKey="Karnoub, M" sort="Karnoub, M" uniqKey="Karnoub M" first="M" last="Karnoub">M. Karnoub</name><name sortKey="Li, M" sort="Li, M" uniqKey="Li M" first="M" last="Li">M. Li</name><name sortKey="Renschler, M F" sort="Renschler, M F" uniqKey="Renschler M" first="M F" last="Renschler">M F Renschler</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Del Vecchio, M" sort="Del Vecchio, M" uniqKey="Del Vecchio M" first="M" last="Del Vecchio">M. Del Vecchio</name></region><name sortKey="Testori, A" sort="Testori, A" uniqKey="Testori A" first="A" last="Testori">A. Testori</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Kefford, R" sort="Kefford, R" uniqKey="Kefford R" first="R" last="Kefford">R. Kefford</name></region><name sortKey="Haydon, A" sort="Haydon, A" uniqKey="Haydon A" first="A" last="Haydon">A. Haydon</name></country><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Loquai, C" sort="Loquai, C" uniqKey="Loquai C" first="C" last="Loquai">C. Loquai</name></region><name sortKey="Gutzmer, R" sort="Gutzmer, R" uniqKey="Gutzmer R" first="R" last="Gutzmer">R. Gutzmer</name><name sortKey="Hauschild, A" sort="Hauschild, A" uniqKey="Hauschild A" first="A" last="Hauschild">A. Hauschild</name></country><country name="France"><noRegion><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C" last="Robert">C. Robert</name></noRegion><name sortKey="Grob, J J" sort="Grob, J J" uniqKey="Grob J" first="J J" last="Grob">J J Grob</name></country><country name="Canada"><region name="Angleterre"><name sortKey="Ernst, S" sort="Ernst, S" uniqKey="Ernst S" first="S" last="Ernst">S. Ernst</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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